The nucleoside analogues are an important class of antiviral agents now commonly used in the therapy of human immunodeficiency virus (HIV) infection, hepatitis B virus (HBV), hepatitis C virus (HCV), cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella-zoster (VZV) infection.
Which antiviral drug is thymidine analog?
thymidine and deoxythymidine analogues: stavudine (d4T) telbivudine (hepatitis B) zidovudine (azidothymidine, or AZT)(HIV)
Is acyclovir a nucleoside analog?
Acyclovir (9-[2-hydroxymethyl]guanine) is a nucleoside analog that selectively inhibits the replication of herpes simplex virus types 1 and 2 (HSV-1, HSV-2) and varicella-zoster virus (VZV). After intracellular uptake, it is converted to acyclovir monophosphate by virally-encoded thymidine kinase.
How do nucleotide analogues work as antiviral drugs?
Antiviral nucleotides are nucleotide analogs that repress the viral reproduction by interfering with several key mechanisms of viral nucleic acid replication. They compete with natural dNTP/NTP substrates for the incorporation into the nascent viral nucleic acid thereby leading to chain termination or mutagenesis (Tab.
Is Remdesivir a nucleoside analog?
Remdesivir is a nucleoside analog, one of the oldest classes of antiviral drugs. It works by blocking the RNA polymerase that coronaviruses and related RNA viruses need to replicate their genomes and proliferate in the host body.
What is a guanine analog?
Acycloguanosine (also called acyclovir) is an analogue of guanine and is one of the most commonly used antiviral drugs. It is an effective treatment for herpes simplex virus infection. Also, base analogues can inhibit DNA synthesis by inhibiting certain enzymes.
What is the brand name of acyclovir?
ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpes viruses. ZOVIRAX Ointment 5% is a formulation for topical administration.
Is acyclovir a dialysis?
Due to its low volume of distribution (0.6 L/kg), low protein binding (about 15%) and water solubility, acyclovir is an example of the ideal drug that can be removed by hemodialysis.
What are analogs in medicine?
Analogue. A drug that is similar to the drug from which it is derived.
What class drug is remdesivir?
Remdesivir injection is used to treat coronavirus disease 2019 (COVID-19 infection) caused by the SARS-CoV-2 virus in hospitalized adults and children 12 years of age and older who weigh at least 88 pounds (40 kg). Remdesivir is in a class of medications called antivirals.
What are the guanosine and deoxyguanosine analogues?
guanosine and deoxyguanosine analogues: abacavir (HIV) aciclovir entecavir (hepatitis B) 1 abacavir (HIV) 2 aciclovir 3 entecavir (hepatitis B)
What are purine analogues used as antineoplastic agents?
The purine analogues used as antineoplastic agents are a group of agents with similar structures, but somewhat different mechanisms of action, pharmacokinetics, indications and adverse effects. These agents are nucleoside analogues and are considered antimetabolites, interfering or competing with nu …
What are the different nucleoside analogs of HIV?
Nucleoside analogue drugs include: deoxyadenosine analogues: didanosine (ddI)(HIV) vidarabine (antiviral) adenosine analogues: BCX4430 (Ebola)
Are there any nucleoside analogs of reverse transcriptase inhibitors?
There is a large family of nucleoside analogue reverse transcriptase inhibitors, because DNA production by reverse transcriptase is very different from normal human DNA replication, so it is possible to design nucleoside analogues that are preferentially incorporated by the former.
