Swelling, redness, pain, or soreness at the injection site may occur. This medication may also rarely cause upset stomach, nausea, vomiting, or diarrhea. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
What is the action of imipenem?
Imipenem + cilastatin is a beta-lactam antibiotic of the carbapenems class with a broad spectrum of activity. The mechanism of action is similar to the other beta-lactam antibiotics, which is to inactivate the penicillin-binding proteins (PBP) and cause cell wall lysis, or interfere with cell wall formation.
How long does it take for imipenem to work?
This medicine must be given slowly, and the infusion can take 20 to 60 minutes to complete.
Is imipenem given IV?
For Intravenous Injection Only The dosage recommendations for PRIMAXIN represent the quantity of imipenem to be administered. An equivalent amount of cilastatin is also present in the solution. These doses should be used for patients with creatinine clearance of greater than or equal to 90 mL/min.
What is the purpose of the cilastatin?
Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections.
Why is cilastatin typically given in combination with imipenem?
Because imipenem is rapidly inactivated by renal dehydropeptidase I (DHP-1), it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem.
Why imipenem is given with cilastatin?
The use of a fixed combination of imipenem and cilastatin is motivated by the increases in urinary recovery of imipenem with the combination and by the elimination of the nephrotoxic potential associated with the administration of imipenem alone.
Why we use cilastatin with imipenem?
Imipenem is in a class of medications called carbapenem antibiotics. It works by killing bacteria. Cilastatin is in a class of medications called dehydropeptidase inhibitors. It works by helping imipenem stay active in your body for a longer period of time.
What is cilastatin imipenem?
Cilastatin is in a class of medications called dehydropeptidase inhibitors. It works by helping imipenem stay active in your body for a longer period of time. Antibiotics such as imipenem and cilastatin injection will not work for colds, flu, or other viral infections.
What does cilastatin do for imipenem?
Why imipenem is administered with cilastatin?
Who makes imipenem cilastatin?
KENILWORTH, N.J.–(BUSINESS WIRE)–Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved RECARBRIO™ (imipenem, cilastatin, and relebactam) for injection, 1.25 grams, a new combination antibacterial.
