The trifluoromethyl group is a functional group that has the formula -CF3.
What is CF3 used for?
The trifluoromethyl group (abbreviated CF3) is a component of several commonly used drugs, including the antidepressant Prozac, arthritis medication Celebrex and Januvia, used to treat diabetes symptoms.
Is CF3 is a nucleophile or electrophile?
Traditionally, the nucleophilic trifluoromethylation reaction involves an electrophile and the CF3 anion, while the electrophilic trifluoromethylation reaction involves a nucleophile and the CF3 cation.
Is fluoroform soluble in water?
Fluoroform
| Names | |
|---|---|
| Solubility in water | 1 g/l |
| Solubility in organic solvents | Soluble |
| Vapor pressure | 4.38 MPa at 20 °C |
| Henry’s law constant (kH) | 0.013 mol·kg−1·bar−1 |
What is the Iupac name of CF3?
CF3 : Summary
| Code | CF3 |
|---|---|
| Molecule name | 9,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDE |
| Systematic names | Program Version Name ACDLabs 10.04 9,9,9-trifluoro-8-oxo-N-phenylnonanamide OpenEye OEToolkits 1.5.0 9,9,9-trifluoro-8-oxo-N-phenyl-nonanamide |
| Formula | C15 H18 F3 N O2 |
| Formal charge | 0 |
Is CF3 radical polar or nonpolar?
So this molecule has no net dipole movement. In the case of , the 2 groups occupy two of the equitorial positions & the 3 group occupy the remaining 3 orbitals. So this molecule has net dipole movement. In short, is non-polar in nature & is polar in nature.
Is CF3 a functional group?
Common methods for introducing the trifluoromethyl group (CF3 group) into organic compounds are categorized into three; 1) the use of building blocks containing CF3 group, 2) trifluoromethylation by the use of trifluoromethylating agents such as CF3-TMS, FSO2CO2Me, CF3I, etc., and 3) the transformation of a functional …
What is the molecular geometry of CF3?
pyramidal
The method has been applied to a prototype system, the “CF3 radical. The results confirm a pyramidal structure with an F-C-F bond angle 0= 109.5~ ~ and a C-F bond length of 1″30-1’35 A_.
Is CCl3 ortho or meta directing?
-CCl3 and – Cl are the meta director.
Why is CF3 an electron withdrawing group?
CF3 is VERY inductively electron-withdrawing (three fluorines on the same carbon, all quite electronegative…). Carbocations are inherently electron-deficient/electropositive. It’s unfavorable to attempt to draw electron density away from wherever there isn’t much.
Is CHF3 a greenhouse gas?
HFC-23 (also known as CHF3, fluoroform or trifluoromethane) is a potent greenhouse gas (GHG), with a global warming potential (GWP) of 14 800 for a 100-year time horizon.
Is CHF3 polar or non polar?
The molecules is perfectly symmetrical, so every electron pair on each fluorine cancels out the electron pairs of every other fluorine. For this reason, this molecule is non-polar.
When was the first trifluoromethyltrimethylsilane prepared?
In 1969 Kobayashi & Kumadaki adapted their protocol for trifluoromethylations. Preparation of the trifluoromethyltrimethylsilane was reported by Ingo Ruppert in 1984. In 1989, Prakash and Olah first reported activation of TMSCF 3 by fluoride to perform nucleophilic trifluoromethylation of carbonyl compounds.
What are the conditions for efficient trifluoromethylation?
Aromatic and heteroaromatic systems with varying stereoelectronics are efficiently trifluoromethylated under these standard conditions (top, generalized reaction). Substrate scope includes electron-rich five-atom heteroarenes ( a ), electron-deficient six-atom heteroarenes ( b ), and unactivated arenes ( c ).
What is the chemical formula for trifluoromethyl sulfone?
Trifluoromethyl sulfone (PhSO 2 CF 3) and trifluoromethyl sulfoxide (PhSOCF 3) can be used for trifluoromethylations of electrophiles
Can trifluoromethyl anion be isolated in condensed phase?
In nucleophilic trifluoromethylation the active species is the CF 3− anion. It was, however, widely believed that the trifluoromethyl anion is a transient species and thus cannot be isolated or observed in the condensed phase.
