Adefovir is used to treat chronic (long-term) hepatitis B infection (swelling of the liver caused by a virus) in adults and children 12 years of age and older. Adefovir is in a class of medications called nucleotide analogs. It works by decreasing the amount of hepatitis B virus (HBV) in the body.
Is adefovir an antiviral?
Adefovir is an antiviral medicine that is used to treat chronic hepatitis B in adults and children at least 12 years old. Adefovir is not a cure for chronic hepatitis B. Adefovir may also be used for purposes not listed in this medication guide.
What is the mechanism of action of Adefovir?
Microbiology Mechanism of Action: Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.
Is Adefovir a prodrug?
Adefovir is a prescription medicine used to treat (chronic) infections with hepatitis B virus. A prodrug form of adefovir was previously called bis-POM PMEA, with trade names Preveon and Hepsera. It is an orally administered nucleotide analog reverse-transcriptase inhibitor (ntRTI).
What are the side effects of adefovir?
SIDE EFFECTS: Weakness, headache, fever, increased cough, nausea, vomiting, diarrhea, or gas may occur. If any of these effects persist or worsen, notify your doctor promptly.
What does lamivudine treat?
It works by decreasing the amount of HIV and hepatitis B in the blood. Although lamivudine does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer.
What kind of drug is telbivudine?
Telbivudine is in a class of medications called nucleoside analogues. It works by decreasing the amount of hepatitis B virus (HBV) in the body. Telbivudine does not cure hepatitis B and may not prevent complications of chronic hepatitis B, such as cirrhosis of the liver or liver cancer.
Is adefovir dipivoxil effective?
Conclusion: Oral adefovir dipivoxil is effective and generally well tolerated in HBeAg-positive and -negative patients chronically infected with wild-type or lamivudine-resistant HBV. Few resistant HBV mutants have emerged to date.
Why is cidofovir given with probenecid?
Concomitant oral probenecid decreases both the renal clearance of cidofovir and the incidence of nephrotoxicity, presumably by blocking its active tubular secretion. This is the basis of the clinical use of concomitant probenecid as a nephroprotectant during cidofovir therapy.
What is lamivudine side effect?
Lamivudine is generally a safe drug, with fewer side effects than other nucleoside reverse transcriptase inhibitors (NRTIs). Its most common side effects are headache, fatigue, and nausea which generally subside over time. Other side effects include decreased appetite, diarrhoea, skin rash, and abdominal pain.
Is lamivudine an antiviral?
Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is also used to treat chronic hepatitis B when other options are not possible. It is effective against both HIV-1 and HIV-2….Lamivudine.
| Clinical data | |
|---|---|
| PubChem CID | 60825 |
| DrugBank | DB00709 |
| ChemSpider | 66068 |
| UNII | 2T8Q726O95 |
What class of drug is adefovir?
Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2- (6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis (t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.
What is adadefovir and what is it for?
Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2- (6-amino-9H-purin-9-yl)ethoxy group.
Is adefovir dipivoxil a prodrug?
Adefovir dipivoxil is a prodrug of adefovir, an acyclic nucleotide analog antiviral agent. Following initial diester hydrolysis in vivo to form adefovir, the drug undergoes subsequent phosphorylation by cellular enzymes to form its active metabolite, adefovir diphosphate.
What is the role of ampicillin in HIV?
It has a role as a HIV-1 reverse transcriptase inhibitor, a drug metabolite, an antiviral drug, a nephrotoxic agent and a DNA synthesis inhibitor. It is a member of 6-aminopurines, an ether and a member of phosphonic acids. It derives from an adenine. It is a conjugate acid of an adefovir (1-).
