c-Myc is a multifunctional transcription factor which drives the multiple synthetic functions necessary for rapid cell division while at the same time inhibiting expression of genes with antiproliferative functions. Because of its propensity to induce apoptosis, its expression is tightly regulated.
Which genes does c-Myc activate for transcription?
c-Myc also activates RNA pol III transcriptional activity through its association with TFIIIB. The association between c-Myc and TFIIIB is observed within the promoter regions of 5S rRNA and tRNA codons and correlates with an increase in the transcription of these genes (Gomez-Roman et al., 2003).
What genes does Myc regulate?
Myc-Regulated Transcriptional Network. These include ribosomal proteins, translation factors, RNA polymerase subunits and > 100 genes in TCA cycle, glycolysis, and biosynthesis. These observations support the idea that Myc regulate general protein synthesis machinery and thereby influences cell size control (36, 37).
What is the difference between c-myc and N myc?
c-Myc is broadly overexpressed in both blood-borne and solid tumors. N-myc is most frequently overexpressed in solid cancers of neural origin, such as neuroblastoma and glioma.
Is C-MYC a tumor suppressor gene?
c-Myc stimulates genes involved in protein biosynthesis, cancer metabolism, transcription factors, and cell-cycle genes, and some microRNAs while inhibiting expression of other microRNAs and some tumor suppressor genes (38).
What is the difference between C-Myc and N myc?
What is the role of c-myc?
c-Myc is a multifunctional transcription factor which drives the multiple synthetic functions necessary for rapid cell division while at the same time, inhibiting expression of genes with antiproliferative functions. Because of its propensity to induce apoptosis, its expression is tightly regulated.
How does the mutation of Myc alter the cell cycle?
Myc transcription factor leads to upregulation of several genes which are involved in cell cycle progression, apoptosis, and cellular transformation, leading to increased cell number and thus, cancer.
