Carbopol 974P is a polymer used as a lacrimal substitute to treat symptoms associated with dry eyes.
What is chemical name of Carbopol?
1 Polyacrylic acid (carbomer; carbopol)
What is the chemical formula of Carbomer?
(C3H4O2)n
Polyacrylic acid/Formula
Is Carbopol a chemical?
Products within the Carbopol polymer family are chemically similar in that they are all high molecular weight, crosslinked polyacrylic acid polymers. However, these gel forming polymers differ by their chemical crosslinking and can be grouped into the following categories.
What is the difference between Carbomer and Carbopol?
Carbopol® polymer is a product brand name of The Lubrizol Corporation. In contrast, “Carbomer” is one of the generic names that can be used to describe Carbopol® polymers. Carbomer can be defined as a high molecular weight polymer of acrylic acid crosslinked with allyl ethers of polyalcohols.
What is the difference between Carbomer 940 and 980?
The key difference between carbomer 940 and 980 is that carbomer 940 is important as a rheological modifier, while carbomer 980 is important as a thickening agent. Carbomer is the market name of polyacrylate polymer.
Which solution becomes gel at tear pH?
The 0.4% w/v carbopol/0.5% w/v chitosan based in situ gelling system was in liquid state at room temperature and at the pH formulated (pH 6.0) and underwent rapid transition into the viscous gel phase at the pH of the tear fluid (lacrimal fluid) (pH 7.4).
Is Carbopol soluble in alcohol?
The pH of a 0.5% to 1.0% dispersion is in the range of 2.5 to 3.5. Carbomers are soluble in water; after neutralization, they are soluble in 95% ethanol and glycerin.
How do you make Carbopol solution?
Begin by mixing the water with moderate agitation (800-1200 rpm). Very slowly sift the Carbopol® polymer into the vortex. Before adding the dry Carbopol® polymers to the tank, break up any lumps that have formed in the polymer due to static electricity or humid conditions.
At what pH are the Carbopol solutions forming gel?
Carbopol is a polyacrylicacid (PAA) polymer, which shows a sol to gel transition in aqueous solution as the pH is raised above its pKa of about 5.5 [10].
What is carbopol 974p?
Carbopol 974P is a highly carboxylated polymer composed of lightly cross-linked polyacrylic acid with a broad-spectrum mechanism based on acidification of pathogens. It was under development by ReProtect LLC. It is a gel that may help both block the spread of sexually transmitted diseases and reduce unwanted pregnancies.
What is the composition of the 974p NF?
Carbopol 974P NF, as well as all oral-grade Carbopol polymers, is solely polymerized in ethyl acetate, which is a toxicologically preferred class III solvent. The toxicity of carbomers has been summarized by the Cosmetic Ingredient Review Expert Panel in their assessment of the safety of the carbomers for cosmetic ingredients.
Can carbopol polymers be combined with powder grades polymers?
Powder and granular grade Carbopol polymers can be combined in a formulation to achieve desired release profiles. The release rates can be modulated by incorporating powder grades polymers, such as Carbopol 971P NF or 974P NF, and then blending with Carbopol 71G NF granular polymer.
What is 974p buffer gel made of?
Carbomer 974P is a carbomer that is the major non-aqueous component (5% polymer, 94% water) of a proprietary formulation called BufferGel, which also contains dibasic potassium phosphate, magnesium sulfate, dibasic sodium phosphate, sorbic acid, monobasic sodium phosphate, and disodium EDTA. It is a buffering agent, a microbicide, and a spermicide.
