Aromasin contains the active ingredient exemestane, which is a steroid. Aromasin works by binding to aromatase, the enzyme in the body responsible for turning testosterone (the main sex hormone in males*) into estrogen (the main sex hormone in females*).
Does exemestane really work?
Clinical trial results presented at the 2011 American Society of Clinical Oncology (ASCO) annual meeting showed that the aromatase inhibitor exemestane (Aromasin®)—commonly used to treat early and advanced-stage breast cancer—substantially reduced the risk of invasive breast cancer in postmenopausal women at high risk …
Can exemestane cause weight gain?
The proportion of patients experiencing an excessive weight gain (>10% of their baseline weight) was significantly higher with megestrol acetate than with AROMASIN (17% vs.
Is exemestane a steroid?
Exemestane is known chemically as 6-methylideneandrosta-1,4-diene-3,17-dione. Like the aromatase inhibitors formestane and atamestane, exemestane is a steroid that is structurally similar to 4-androstenedione, the natural substrate of aromatase.
How long does it take for exemestane to lower estrogen?
After a single dose of exemestane 25 mg, the maximal suppression of circulating estrogens occurred 2 to 3 days after dosing and persisted for 4 to 5 days.
Does exemestane lower estrogen?
Phase I studies have demonstrated that exemestane, an irreversible oral aromatase inhibitor, is able to suppress circulating oestrogen levels. In our previous experience, doses ranging from 2.5 to 25 mg induced a similar suppression of oestrogens.
What is the success rate of exemestane?
As first-line treatment, once daily exemestane 25 mg elicited objective and overall success rates of 42 and 58%, compared with 16 and 31% for once daily tamoxifen 20 mg. Exemestane was generally well tolerated in clinical trials at once daily dosages up to 600 mg.
What is male exemestane?
Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14-26 yr of age) were recruited.
Does exemestane cause hair loss?
Hair and skin changes You may have some hair loss or thinning while taking exemestane. However, your hair should return to the way it was before treatment when you stop taking exemestane. A small number of women notice an increase in downy facial hair.
How can I avoid weight gain during hormone therapy?
To balance estrogen levels naturally and prevent the weight gain that happens with an estrogen imbalance, you’ll want to do the following:
- Commit to a regular exercise routine.
- Eat your fiber.
- Eat veggies in the cruciferous family.
- Reduce your exposure to endocrine disruptors.
Does exemestane cause weight gain?
To clarify, the analysis refers to any weight change (upward or downward), and to the worst grade observed on treatment.When one considers the weight gain observed in the exemestane arm versus that observed in the megestrol acetate arm, there seems to be no cause for concern with exemestane.
Is exemestane a chemo drug?
Exemestane (Aromasin) Exemestane is a type of hormone therapy drug and is also known by its brand name, Aromasin. It is a treatment for women with breast cancer who have had their menopause.
What is exemestane used for?
The medicine Exemestane is used to treat Breast Neoplasm
What does exemestane do?
Exemestane is used to treat estrogen receptor-positive breast cancer in women who have gone through menopause. Exemestane is a type of aromatase inhibitor. It works by decreasing the amount of estrogen in the body. Some breast tumors require estrogen to grow.
