The exposome can be defined as the measure of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual’s exposure begins before birth and includes insults from environmental and occupational sources.
What is exposome science?
Exposome research is about discovering the non-genetic drivers of health and disease. Derived from the term exposure, the Exposome represents the totality of exposures we face throughout our lifetime. It also represents the biological responses that arise from external exposures.
Who coined the term exposome?
epidemiologist Christopher Wild
3.1 ‘Discovery’ of the Exposome. In 2005, molecular epidemiologist Christopher Wild coined the term ‘exposome’ in an editorial in the influential journal Cancer Epidemiology, Biomarkers & Prevention.
Why is the exposome important?
The exposome offers health scientists an avenue for integrating research that is currently fractured along lines related to particular diseases and risk factors, and can thereby promote discovery of the key exposures responsible for chronic diseases.
What is external exposome?
Presently, the exposome, the totality of specific and nonspecific external environmental exposures (external exposome) to which a subject is exposed from preconception onward and their consequences at the organ and cell levels (internal exposome), is being considered to explain the inception, development, and …
How our exposome affects our bodies?
The benefits of the exposome are many for both individual and population health research. The exposome can aid in identifying modes of action of stressors, identifying unknown exposures and improving our understanding of disease.
What is omics in biology?
The word omics refers to a field of study in biological sciences that ends with -omics, such as genomics, transcriptomics, proteomics, or metabolomics. The metabolome represents the collection of all metabolites in a biological cell, tissue, organ, or organism, which are the end products of cellular processes.
Are Infections part of the exposome?
In this review, we introduce the concept of the “infectome”, which is the part of the exposome referring to the collection of an individual’s exposures to infectious agents.
How our Exposome affects our bodies?
Are Infections part of the Exposome?
What is exposome in biology?
Exposure Biology and the Exposome. Program Description. Complex environmental exposures from a variety of sources can affect a person’s health. Frequently, we think of exposures as occurring outside of the body, including chemicals, radiation, infectious agents, and lifestyle factors such as diet and exercise.
What is exposome measuring?
Measuring the totality of exposures a person experiences from conception to death along with the associated biological response is referred to as the exposome, a concept that has become increasingly important for discovering environmental causes of disease.
Where can I find information about exposure science and the exposome?
View a list of publications related to the exposome in PubMed. This series of webinars include presentations and interactive discussions on research efforts in exposure science and the exposome. For up-to-date information, go to the NIEHS Exposure Science and the Exposome Webinar Series home webpage.
What is the importance of exposome research?
One important aspect of the exposome will be adherence to strict ethical principles as the exposome is deciphered. This will be paramount to ensure that the rights of individuals are not compromised when determining exposures and the relationship to their health. What are the research needs?
