Hand-foot syndrome (also called palmar-plantar erythrodysesthesia) is a side effect of some chemotherapy drugs that can cause redness, swelling and blistering on the palms of the hands and soles of the feet.
What is palmar and plantar?
Palmar-Plantar Erythrodysesthesia (PPE) – is a dermatologic toxicity induced by some chemotherapy drugs also. known as Hand-Foot Syndrome (HFS), and is characterized by tingling and tenderness developing to symmetrical redness, swelling and pain primarily on the palm of the hand and sole of the foot.
How long does palmar-plantar last?
If you develop a raised temperature contact your treatment team immediately. If your symptoms are severe, your treatment team may recommend delaying, reducing or stopping treatment to make sure they don’t get any worse. Once treatment is stopped symptoms usually reduce within two to four weeks.
Which drug causes palmar plantar Erythrodysesthesia?
Palmar plantar erythrodysesthesia (PPE) or hand-foot syndrome (HFS) or acral erythema is one of the rare side effects of chemotherapeutic agent. It has been commonly reported with capecitabine, docetaxel, 5 fluorouracil, cytarabine.
What causes palmar fasciitis?
Palmar fasciitis and polyarthritis (PFPA) is an uncommon disorder clinically characterized by rapidly developing bilateral arthritis of the hands and fasciitis of the palms. This cancer‑associated syndrome, primarily linked to ovarian cancer, has also been associated with multiple different malignancies.
Which of the following agents puts the patient at risk for developing palmar plantar Erythrodysesthesia?
The most likely causative agents are cytarabine, doxorubicin, liposomal doxorubicin (Doxil, Alza), fluorouracil and capecitabine (Xeloda, Roche). The table lists other agents that are believed to cause PPE. As many as 33% of patients receiving high doses of cytarabine (>1 g/m2) are at risk.
How can palmar plantar Erythrodysesthesia be prevented?
Preventing and managing hand-foot syndrome
- Limit the use of hot water on your hands and feet when washing dishes or bathing.
- Take cool showers or baths.
- Cool your hands and feet.
- Avoid sources of heat, including saunas, sitting in the sun, or sitting in front of a sunny window.
Which of the following agents puts the patient at high risk for developing palmar plantar Erythrodysesthesia?
