Vaughan-Williams Classification of Antiarrhythmic Drugs
| Condition | Drug |
|---|---|
| Sinus tachycardia | Class II, IV |
| Atrial fibrillation/flutter | Class IA, IC, II, III, IV digitalis |
| Paroxysmal supraventricular tachycardia | Class IA, IC, II, III, IV adenosine |
| AV block | atropine |
How are antiarrhythmic drugs classified?
Class I agents block sodium channels. Class II agents are Beta blockers. Class III agents prolong the cardiac action potential. Class IV agents are calcium channel blockers.
What are Class 3 antiarrhythmic drugs?
Class 3 antiarrhythmics are drugs that block cardiac tissue K channels. The medications in this class include amiodarone, dronedarone, sotalol, ibutilide, dofetilide, and bretylium.
What is a class 3 antiarrhythmic?
Class III antiarrhythmic drugs act by blocking repolarising currents and thereby prolong the effective refractory period of the myocardium. This is believed to facilitate termination of re-entry tachyarrhythmias. This class of drugs is developed for treatment of both supraventricular and ventricular arrhythmias.
Which antiarrhythmic drug has both Class 2 and 3 activity?
The clinical use of sotalol has been limited by both its antiarrhythmic efficacy (a common issue for most antiarrhythmics), and its Class III-related associated side effect of Torsade de pointes (1.5-2% incidence).
What are the Class 2 antiarrhythmics?
Class II agents include atenolol, esmolol, propranolol, and metoprolol.
What is the Vaughan Williams classification system?
Vaughan Williams classification (redirected from Vaughan Williams Classification of Antiarrhythmic Drugs) Vaughan Williams classification Cardiology The system by EM Vaughan Williams, used to categorize effects of antiarrhythmics by class. See Antiarrhythmic drugs. Cf Sicilian Gambit.
What is Vaughan Williams system in cardiology?
Cardiology The system by EM Vaughan Williams, used to categorize effects of antiarrhythmics by class. See Antiarrhythmic drugs. Cf Sicilian Gambit. Vaughan Williams Classification of Antiarrhythmic Drugs Class ISodium-channel blockers
What is the classification of antiarrhythmic drugs?
Vaughan Williams Classification of Antiarrhythmic Drugs Class I Sodium-channel blockers IA Moderately slow conduction, moderately prolonged duration of action potential–active in atria, ventricles; most cardiotoxic group Examples Quinidine, procainamide, diisopyramide
Which class of antiarrhythmic drugs block potassium and calcium channels?
For example, amiodarone, a Class III antiarrhythmic, also has sodium and calcium-channel blocking actions. Many of the Class I compounds also affect potassium channels.
