When obtaining Food and Drug Administration (FDA) approval, daptomycin was dosed at 4–6 mg/kg of actual body weight (ABW) based on indication. However, obese patients with a BMI ⩾30 mg/m2 were not well represented in the clinical trials.
Is daptomycin dosed on ideal body weight?
Per the US Food and Drug Administration labeling, daptomycin is recommended to be dosed based on total body weight (TBW). This involves pharmacokinetic assumptions, including that clearance (CL) and volume of distribution (Vd) change proportionately with TBW—making TBW dosing appropriate in obese patients.
How are antibiotics dosed for obesity?
American consensus guidelines recommend that initial doses for all patients including the obese should be based on TBW and then adjusted based on SVCs (97). Most published data support the use of the Cockcroft-Gault equation with TBW to calculate CrCl and vancomycin clearance in non-obese patients.
How is daptomycin dosed?
Dosage In Adults For cSSSI Administer CUBICIN 4 mg/kg to adult patients intravenously in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.
Is daptomycin renally dosed?
Renal Dosing Daptomycin is eliminated primarily by the kidneys; therefore, a modification of CUBICIN dosage is recommended for patients with CLCR <30 mL/min, including patients receiving hemodialysis or continuous ambulatory peritoneal dialysis (CAPD).
Are antibiotics dosed by weight?
Whereas children’s antibiotic dosing is generally calculated according to body mass, for adults, no such system is in place, and for those drugs that do have body mass specific guidelines for dosing, adherence is “inadequate,” according to the authors.
Are antibiotic doses based on weight?
The usual dose is 20 to 40 milligrams (mg) per kilogram (kg) of body weight per day, divided and given every 8 hours, or 25 to 45 mg per kg of body weight per day, divided and given every 12 hours. Infants 3 months of age and younger—Dose is based on body weight and must be determined by your doctor.
What should I monitor with daptomycin?
Patients receiving daptomycin therapy should be monitored to ensure the safe administration of the medication. Baseline renal function tests are recommended to assess renal impairment and the necessity of dosage adjustments.
Is daptomycin renally adjusted?
Does daptomycin cover MRSA?
Daptomycin is used to treat various bacterial infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Daptomycin has numerous FDA-approved and off-label clinical uses.
Why is adjusted body weight used for obese patients?
Adjusted body weight is used by some dietitians for obese patients when calculating energy requirements. Adipose tissue is not as metabolically active as lean tissue, so using actual body weight in equations to predict BEE for obese persons may result in an overestimation.
How to dose daptomycin?
The recommended dose range for daptomycin in adults is based on weight and ranges from 4 mg/kg to 6 mg/kg once daily for 7-14 days for serious skin infections or 2-6 weeks for bloodstream and heart valve infections. Daptomycin should be injected over 2 minutes or infused over 30 minutes.
How much is daptomycin?
Daptomycin Prices. This daptomycin price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. The cost for daptomycin intravenous powder for injection 350 mg is around $241 for a supply of 1 powder for injection, depending on the pharmacy you visit.
